Relationship between dental caries and phosphocalcic metabolism in children with severe central nervous system diseases caused by perinatal hypoxia

Abstract

The purpose of this paper was to study the relationship between dental caries damage and markers of phosphocalcic metabolism in children with severe diseases of the central nervous system (CNS) caused by perinatal hypoxia. To highlight the impact of metabolic disorders on the susceptibility to dental caries of children with severe CNS disease, were studied the biochemical markers of redox processes, bone and phosphocalcic metabolism in blood serum and oral fluid (OF). The study found a chronic disorder of redox processes, phosphocalcic metabolism at the macro and local level that significantly influences the degree of dental caries of children with severe CNS pathology confirms by: increased lactate level and lactate dehydrogenase (LDH) activity; reduced thermolabile alkaline phosphatase (TLAP) activity in the blood serum and OF, as well as a statistically significant increase in tartrate–resistant acid phosphatase (TRAP) activity in the blood serum as the statistically significant decrease, below the norm, of the level of Ca, Mg and vitamin D3 in the blood serum as well as the significant reduction of the Ca/Pi ratio in OF. Conclusions: the detection in children with CNS diseases caused by perinatal hypoxia of important caries risk factors and indicators of aggressive evolution of DC such as increased concentration of anaerobic glycolysis products and disorders of phosphocalcic metabolism, requires the deepening of interdisciplinary studies and the complex approach in the planning of preventive measures, developed by multipurpose teams of specialists.