Magnetic Nanofluid Temperature Distribution with Different Concentrations and Diffusion of MNPs

Abstract

distribution, rate. Hyperthermia therapy using magnetic nanofluid is one method to regulate and optimize temperature, which is a substantial challenge in practice. The generated heat through the magnetic coil using magnetic nanoparticles in the tumor is closely associated with the dispersion of particles, frequency, magnetic field intensity, and the property of the tissue. Therefore, with magnetic nanoparticles injected into tumor tissue and subjects to an alternating magnetic field with high amplitude and frequency, tumor tissue temperature rises, which could lead to destroying cancer cells. In this study, to simulate the magnetic field intensity at different parts of the experiment and to solve heat transfer equation, a finite element method using COMSOL Multiphysics has been used. Then, to verify our model, an experimental setup was used to measure temperature distribution in an agarose gel with two different nanofluid concentrations for dispersed and concentrated injections. Simulation results have been compared with experimental ones to show the model's accuracy. Results indicate that the magnetic field in different parts of the gel is not the same, but the differences are insignificant. Temperature distribution for both types of nanofluid in dispersed and concentrated injections has a behavior like a polynomial function with a degree of three. Compared to dispersed injection, a higher temperature is observed in concentrated