Preterm Doğum Öngörüsünde Birinci ve Üçüncü Trimester Tam Kan Sayımı Parametrelerinin Karşılaştırılması

Abstract

Introduction: The complete blood count parameters and its combinations, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and mean platelet volume (MPV), are inflammatory markers. In this study, we aimed to demonstrate the possible role of complete blood count parameters (NLR, PLR, and MPV) in predicting preterm birth. Material and Methods: The complete blood count parameters in the first and third trimesters were recorded, as well as the corresponding NLR, PLR, and MPV. The study population was categorized as preterm (n = 94) and term births (n = 953). The preterm birth group was further divided into early preterm (n = 11) and late preterm birth (n = 83) groups. The inflammatory markers were compared between the study groups for the first and third trimesters separately. The alterations between the first and third trimester values were also compared. Results: The first trimester values were similar across the study groups. Moreover, the MPV difference between the first and third trimesters was significantly lower in the preterm group than in the term group (0.0  1.1 vs. 0.2  1.1, p = 0.038). Furthermore, NLR values were higher in the early preterm subgroup than in the late preterm and term groups for the first and third trimesters (first trimester; 4.0  1.2 vs. 3.1  2.0 and 3.1  1.3, p = 0.005; third trimester; 5.3  1.2 vs. 4.0  1.5 and 4.4  2.9, p = 0.013). Conclusion: NLR and MPV predict preterm births in the first trimester and before birth. This enables physicians to take some precautions in preventing preterm delivery.