High Phenolic Extra Virgin Olive Oil Influences the Gut-brain Axis in Individuals Diagnosed with Autism Spectrum Disorder

Constantinos Thoma, A. Papachristou, G. Wozniak
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Abstract

Autism Spectrum Disorder (ASD) is an umbrella term that incorporates a range of neurodevelopmental disorders which affect behaviour, emotion, and communication. In recent years, the effects of dietary habits in individuals with ASD have been mentioned and a distinct correlation has been observed between ASD and gastrointestinal (GI) disorders. We used the Autism Treatment Evaluation Checklist (ATEC) to evaluate whether we can observe differences in behaviour by administering High Phenolic Extra Virgin Olive Oil (HP EVOO) in combination with a special diet to reduce inflammation and consequently improve behaviour. We hypothesise that ASD symptoms will soothe at a proportional rate relative to their severity. Individuals that followed the protocol showed a decrease in severity of their symptoms. Regarding data analysis, we calculated the p-values to evaluate the significance of our results. Our objective is to establish the beneficial influence that HP EVOO has on the gut-brain axis by soothing ASD symptoms.
高酚特级初榨橄榄油对自闭症谱系障碍患者肠脑轴的影响
自闭症谱系障碍(ASD)是一个总称,包含了一系列影响行为、情感和沟通的神经发育障碍。近年来,饮食习惯对ASD患者的影响已被提及,并观察到ASD与胃肠道疾病之间存在明显的相关性。我们使用自闭症治疗评估清单(ATEC)来评估我们是否可以通过使用高酚特级初榨橄榄油(HP EVOO)结合特殊饮食来减少炎症,从而改善行为,从而观察到行为差异。我们假设ASD症状会以相对于其严重程度的比例缓解。遵循该方案的个体症状的严重程度有所减轻。在数据分析方面,我们计算了p值来评估结果的显著性。我们的目标是确定HP EVOO通过缓解ASD症状对肠脑轴的有益影响。
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