Evaluation of Omeprazole in the Treatment of Laryngopharyngeal Reflux Disease: A Single Center, Prospective and Randomized Study

Otorhinolaryngology Clinics An International Journal Pub Date : 1900-01-01 DOI:10.5005/JP-JOURNALS-10003-1186

Kartik Doshi, A. Varghese, D. Badyal, B. Hathiram, V. Khattar

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引用次数: 1

Abstract

Aims: To assess efficacy and safety of omeprazole in laryngitis due to laryngopharyngeal reflux disease (LPRD). Materials and methods: It was a prospective, randomized, open label study conducted in 90 patients with laryngitis due to LPRD. Group A (n = 45) received omeprazole and advice about life style modification, group B (n = 45) received only advice about life style modification. Reflux symptom index (RSI), reflux finding score (RFS), quality of life (QoL) and voice handicap index (VHI) were evaluated at 0, 4 and 8 weeks. Results: Percentage reduction in RSI and RFS was signi ficantly higher in group A after 8 weeks (37 vs 29%, 18 vs 13% respec tively). Excess throat mucus, clearing of throat and erythema of posterior larynx improved considerably in group A compared to group B. Conclusion: Omeprazole could be a significant addition to life style modification in LPRD patients particularly for signs and symptoms, such as excess throat mucus, clearing of throat and erythema of posterior larynx.

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评价奥美拉唑治疗咽喉反流性疾病:一项单中心、前瞻性和随机研究

目的:评价奥美拉唑治疗咽喉反流性疾病(LPRD)所致喉炎的疗效和安全性。材料和方法:这是一项前瞻性、随机、开放标签的研究，对90例LPRD所致喉炎患者进行了研究。A组(n = 45)接受奥美拉唑治疗并接受改变生活方式的建议，B组(n = 45)只接受改变生活方式的建议。分别于0、4、8周评估反流症状指数(RSI)、反流发现评分(RFS)、生活质量(QoL)和语音障碍指数(VHI)。结果:8周后，A组RSI和RFS的减少百分比显著高于对照组(分别为37% vs 29%， 18% vs 13%)。结论:奥美拉唑对LPRD患者生活方式的改善有显著的辅助作用，特别是对喉液过多、喉清、喉后红斑等体征和症状的改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Otorhinolaryngology Clinics An International Journal

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