Comparison of Healing of Allograft and Autogenous Bone Implanted in the Skull Defect of Beagle Dog: Preliminary Animal Study

Abstract

Copyright © 2018. The Korean Academy of Oral & Maxillofacial Implantology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. OPEN ACCESS Purpose: The purpose of this study was to evaluate the healing process af ter autogenous and allogenous bone grafts for calvarial bone defects in beagles. Materials and Methods: Two defects were formed in the skulls of two beagles and then grafted with a f reeze-dried bone allograf t (Double-Oss) and an autogenous bone chip, respectively. The clinical, radiographic, and histomorphometric examination results of the specimens taken 4 and 8 weeks after bone grafting were analyzed. Results: The clinical, radiographic, and histological assessments revealed that 4 and 8 weeks after transplant, the beagle that received an autogenous bone graft was more likely to have high new bone formation than the beagle that had an allogenous bone. Four weeks after the transplant, the proportions of new bone formation were 11.5% and 35.8% in the allogenous and autogenous bones, respectively. Eight weeks af ter the transplant, the proportion of new bone formation with the allogenous bone increased significantly to 41.4% but was still less than the 65.6% with the autogenous bone. Conclusion: The amount of new bone formation was smaller and the formation rate was slower with allogenous bone graft than with autogenous bone graft.