Desmocollin-3 and Cancer

B. Khamar
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引用次数: 6

Abstract

Desmocollin-3[DSC3] is one of the adhesion molecules of cadher in super family found in desmosome and is a major adhesive force of epithelial cells [1-6]. DSC3 is a transmembrane calcium-dependent glycoprotein produced by the endoplasmic reticulum,encoded by the DSC3 gene. DSC3 is expressed, mainly in basal and immediate suprabasal layers of the stratified squamous epithelia [7] like buccal mucosa, esophagus, cervix, fore skin tongue, trachea etc. [3,8]. As an adhesion molecule, DSC3 provides homophilic adhesion i.e. cells expressing DSC3 will adhere to each other at the site of expression but not with others; it also works as a receptor as well as ligand to participate in cell signaling [9].
desmocolin -3与癌症
桥粒蛋白-3 (desmocolin -3[DSC3])是桥粒中发现的超家族黏附分子之一,是上皮细胞的主要黏附力[1-6]。DSC3是一种由内质网产生的跨膜钙依赖性糖蛋白,由DSC3基因编码。DSC3主要表达于层状鳞状上皮[7]的基底层和直接基上层,如颊粘膜、食管、子宫颈、前皮、舌、气管等[3,8]。作为一种粘附分子,DSC3提供亲同性粘附,即表达DSC3的细胞会在表达位点相互粘附,而不会与其他细胞粘附;它也作为受体和配体参与细胞信号传导[9]。
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