NEUROLOGICAL MANIFESTATIONS IN PATIENTS WITH NEW CORONAVIRUS INFECTION COVID-19

Aleksandr S. Golota, D. A. Vologzhanin, T. Kamilova, Sergey G. Sсherbak, S. V. Makarenko
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引用次数: 1

Abstract

Most commonly, COVID-19 presents as a respiratory disease, but a growing body of clinical evidence shows that neurological symptoms and complications contribute significantly to the clinical spectrum of the disease, especially in patients with severe disease. The public health impact of the long-term (or even life-long) consequences of the disease may be much greater than the acute manifestations of SARS-CoV-2 infection. As the pandemic has evolved, the number of neurological manifestations as part of the clinical spectrum of the disease has increased. The diverse neurological manifestations of COVID-19 range from mild symptoms (myalgia, headache, fatigue, dizziness, anosmia, ageusia) to more severe manifestations such as encephalopathy, encephalitis, acute and chronic polyneuropathy. Neurological symptoms and complications of COVID-19 do not necessarily require direct infection of structures in the peripheral or central nervous system, but may occur secondary to a severe systemic reaction to SARS-CoV-2 infection outside the nervous system. The neurotoxicity of SARS-CoV-2 infection may be secondary to immune-mediated pathogenesis and coagulation dysfunction. To substantiate the therapeutic choice, it is necessary to study the pathophysiological processes and clinical trials.
新型冠状病毒感染COVID-19患者的神经学表现
最常见的是,COVID-19表现为一种呼吸道疾病,但越来越多的临床证据表明,神经系统症状和并发症在该病的临床谱系中起着重要作用,特别是在病情严重的患者中。该疾病的长期(甚至终身)后果对公共卫生的影响可能远大于SARS-CoV-2感染的急性表现。随着大流行的演变,作为该疾病临床谱一部分的神经系统表现的数量有所增加。COVID-19的神经系统表现多种多样,从轻度症状(肌痛、头痛、疲劳、头晕、嗅觉丧失、衰老)到较严重的症状,如脑病、脑炎、急性和慢性多发性神经病。COVID-19的神经系统症状和并发症不一定需要直接感染外周或中枢神经系统的结构,但可能继发于神经系统外对SARS-CoV-2感染的严重全身反应。SARS-CoV-2感染的神经毒性可能继发于免疫介导的发病机制和凝血功能障碍。为了证实治疗的选择,有必要对病理生理过程和临床试验进行研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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