The relation of vitamin D level to adverse prognostic factors in Non Hodgkin lymphoma: A single center analysis

Abstract

Vitamin D insufficiency has been found to be associated with higher incidence of NHL, besides the lower levels are linked with poor prognosis. The current study was conducted to assess vitamin D level in newly diagnosed chronic lymphocytic leukemia (CLL) and diffuse large B- cell lymphoma (DLBC) patients. In addition, grade of lymphoma was evaluated with the relation of hypo-vitaminosis D and adverse prognostic parameters. 74 patients (50% CLL and 50% DLBCL) were enrolled in this study. All patients with CLL had vitamin D insufficiency which correlated with advanced Rai and Binet stage. About 91.8% of DLBCL patients had vitamin D insufficiency which correlated with bad ECOG performance, advanced Ann-Arbor staging, high LDH and extranodal involvement. Vitamin D levels in the CLL group were significantly lower than DLBCL group. However, we could not detect an impact of the severity of deficiency on the lymphoma grade.