THE ROLE OF FIBRINOGEN IN COAGULATION STATUS, METHODS OF ITS CORRECTION. LITERATURE REVIEW AND CLINICAL CASE

Abstract

Fibrinogen is an important protein of hemostasis. In blood plasma, its concentration is the highest of all coagulation proteins - clotting factors. When coagulation cascade activated, thrombin splits fibrinogen and triggers fibrin polymerization to the form required for efficient clot formation. In acute blood loss, dilutional coagulopathy may develop, causing decreasing fibrinogen levels, which is critical for clot formation. Recently, there has been emerged and rapidly increased the interest in fibrinogen replacement during acute bleeding as a point of the bleeding treatment and prevention, especially in the perioperative patients. This study reviews current data on relevant plasma fibrinogen levels and dosing in various clinical settings, as well as clinical experience with the use of fibrinogen concentrate in patients with dilutional coagulopathy and disseminated Intravascular coagulation syndrome is described.