THUMP domain containing 2 protein possibly induces resistance to cisplatin and 5‐fluorouracil in in vitro human esophageal squamous cell carcinoma cells as revealed by transposon activation mutagenesis

Abstract

Although chemotherapy is a core treatment for esophageal cancer, some patients develop drug resistance. Gene screening with transposons (i.e. mobile genetic elements) is a novel procedure for identifying chemotherapy‐resistant genes. Transposon insertion can randomly affect nearby gene expression. By identifying the affected genes, candidate genes can be found. The present study aimed to identify cisplatin (CDDP)/5‐fluorouracil (5‐FU)‐resistant genes in in vitro human esophageal squamous cell carcinoma with transposons.