{"title":"Targeting SWI/SNF metabolic vulnerabilities in cancer","authors":"M. Soeung, L. Perelli, A. Sgambato, G. Genovese","doi":"10.48286/aro.2021.31","DOIUrl":null,"url":null,"abstract":"The SWI/SNF (Switch/Sucrose non-fermentable) complex is a key epigenetic regulator that is conserved across different species. While its functions as a gene expression regulator have been widely characterized, new evidences suggest that it can act as a fundamental modulator of metabolic pathways both in physiological and pathological processes. In this review, we summarized the most recent literature addressing molecular interactions involving members of the SWI/SNF complex and metabolic pathways. We focused on how genetic 1 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy 4 Scientific Direction, Centro di Riferimento Oncologico della Basilicata IRCCS-CROB, Rionero in Vulture, Potenza, Italy 5 David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA","PeriodicalId":148778,"journal":{"name":"Annals of Research in Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Research in Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.48286/aro.2021.31","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The SWI/SNF (Switch/Sucrose non-fermentable) complex is a key epigenetic regulator that is conserved across different species. While its functions as a gene expression regulator have been widely characterized, new evidences suggest that it can act as a fundamental modulator of metabolic pathways both in physiological and pathological processes. In this review, we summarized the most recent literature addressing molecular interactions involving members of the SWI/SNF complex and metabolic pathways. We focused on how genetic 1 Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 3 Department of Translational Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome, Italy 4 Scientific Direction, Centro di Riferimento Oncologico della Basilicata IRCCS-CROB, Rionero in Vulture, Potenza, Italy 5 David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
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