Jamil Ahmed Lakhair, Z. H. Tanveer, Shaher Murad, S. Shahina, A. Fatah, E. Fatima
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引用次数: 0
Abstract
Hyperglycemia, hypertension, and hyperlipidemia are known as metabolic syndrome. In presence of high levels of blood LDL particles, free radicals (ROS), macrophages, cytokines, platelets, histamine, 5HT get involved in LDL oxidation, leading to formation of atherosclerotic plaques which get deposited in endothelium of coronary arteries causing coronary artery disease (CAD). Psyllium fibers and Ficus Carica (FC) are being considered to be useful in treating hyperlipidemia, hypertension, and hyperglycemia. This study was conducted to determine hypotensive, hypolipidemic, and hypoglycemic potential of Psyllium husk and FC. Study was conducted in National hospital, Lahore, Pakistan from January to April 2020. Seventy five hyperlipidemic, hypertensive and diabetic patients were enrolled selected from the hospital with their consent. They were divided in three groups ie 25 patients in each group. Group-1 was on placebo, group-2 was on 15 grams psyllium husk to be used in three divided doses. Group-3 was on 12 grams FC to be taken in three divided doses daily for two months. Their Lipid profile, FBS, and hypertension were determined before and after two months therapy by these two agents. Two analyze data we used SPSS version 10.01.001 2015 and t test was applied to determine changes in the tested parameters. In two months therapy by psyllium husk in 24 patients TG, TC, LDL-c was reduced 21.48, 10.09, 24.17 mg/dl respectively. HDL was increased 12.38 mg/dl in this group. FBS reduction was 28.66 mg/dl, systolic BP 6.30, and diastolic BP reduced in this group 7.52 mm of mg. We then concluded that FC and PH have good enough potential to normalize lipid profile, reduce BP, and FBS in patients suffering from metabolic syndrome.
高血糖、高血压和高脂血症被称为代谢综合征。在高水平的血液LDL颗粒、自由基(ROS)、巨噬细胞、细胞因子、血小板、组胺、5HT参与LDL氧化,导致动脉粥样硬化斑块的形成,这些斑块沉积在冠状动脉的内皮中,导致冠状动脉疾病(CAD)。车前草纤维和无花果(FC)被认为对治疗高脂血症、高血压和高血糖症有用。本研究旨在测定车前草壳和FC的降压、降血脂和降糖潜能。研究于2020年1月至4月在巴基斯坦拉合尔国家医院进行。在患者同意的情况下,从该院选择75例高脂血症、高血压和糖尿病患者。他们被分为三组,每组25名患者。组1服用安慰剂,组2服用车前草皮15克,分三次服用。3组服用12克FC,每天分三次服用,连续两个月。在这两种药物治疗前后两个月分别测定他们的血脂、FBS和高血压。两个分析数据我们使用SPSS version 10.01.001 2015,并采用t检验来确定被测参数的变化。车前草皮治疗2个月后,24例患者TG、TC、LDL-c分别降低21.48、10.09、24.17 mg/dl。HDL升高12.38 mg/dl。FBS降低28.66 mg/dl,收缩压降低6.30,舒张压降低7.52 mm / mg。因此,我们得出结论,FC和PH有足够的潜力使代谢综合征患者的血脂水平正常化,降低血压和FBS。