Electric Field Distribution Measurement for electrocapacitive cancer therapy by using Wire Mesh Tomography

Abstract

Although low energy alternating electric field are gaining an acceptance for electrotherapy of cancer treatment, recent studies have only discussed the electric field distribution characteristics theoretically using numerical approaches. In order to obtain the optimum benefit of low energy alternating electric field, an accurate vector of the low energy alternating electric field in the region of cancer cells should be achieved. In this study, we propose a novel electric field measurement method by using wire mesh tomography (WMT) in order to obtain a feedback to minimize the error of numerical simulation of ECCT. The WMT sensor consists of 8×8 copper wire matrix in a circular shape vessel with diameter 12 cm. The cross-sectional of biomaterial phantoms of human head model with known electrical properties a priori were inserted the wire mesh sensor and were exposed by low energy alternating electric field by using ElectroCapacitive Cancer Therapy (ECCT) system based on numerical and experimental studies. The electric field value in the air medium has the highest value compared to the value of electric field in grey matter matter and cancer cells. And the electric field value in grey matter matter has a higher value than the value of the electric field in the cancer cell. This study can be a new science in measuring electric field so that electric field-based treatment can be more optimal in its planning.