Ameliorative Effect of Honey and Bee Venom against Renal Injury Induced by Lipopolysaccharide (Lps) And Carbon Tetrachloride (Ccl4) in Male Albino Rats

Abstract

The objective of the study was to assess the potential effect of honey and bee venom (BV) on nephrotoxicity caused by LPS (Lipopolysaccharide) and CCl4 (Carbon Tetrachloride) in rats. Sixty-four male albino rats of an average weight of 120–150 g were included in this study. Rats were divided into 8 equal groups of 8. The results showed that treatment with LPS/CCl4caused in a significant increase in serum urea, creatinine as well as uric acid. The use of honey (25 mg/kg b.wt.) and BV (1 mg/kg b.wt.) attenuates to LPS and CCl4 induced renal dysfunction was demonstrated. Honey and/or BV may therefore be a potential therapeutic method to prevent LPS/CCl4-induced renal dysfunction.