Bandwidth limitation of the electrolytes for DNA sequencing using nanopore sensors

Abstract

DNA sequencing using nanopore-based sensors attracts considerable interests because of the possibility of ultimate sensitivity of single-molecule resolution. Due to the fast DNA translocation speed on the order of microsecond, the sensor requires a wide bandwidth exceeding a megahertz. Such a high frequency signal transmits through the electrolyte and the sensor measures ionic current changes. The electrolyte is essential to dissolve DNA sample into the sensor. However, the bandwidth of the electrolyte has not been considered yet. This study presents the bandwidth limitation of the electrolyte and we believe it should be considered when using DNA sequencing method via high frequency signal detection through the electrolyte.