Dynamic evaluation and control of blood clotting using a microfluidic platform for high-throughput diagnostics

M. Combariza, Xinghuo Yu, W. Nesbitt, F. Tovar-Lopez, D. Rabus, A. Mitchell
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Abstract

Microfluidic technology has the potential to revolutionise blood-clotting diagnostics by incorporating key physiological blood flow conditions like shear rate. In this paper we present a customised dynamic microfluidic system, which evaluates the blood clotting response to multiple conditions of shear rate on a single microchannel. The system can achieve high-throughput testing through use of an advanced fluid control system, which provides with rapid and precise regulation of the blood flow conditions in the platform. We present experimental results that demonstrate the potential of this platform to develop into a high-throughput, low-cost, blood-clotting diagnostics device.
利用微流控平台进行高通量诊断的血液凝固动态评估和控制
微流体技术通过结合关键的生理血流条件,如剪切速率,有可能彻底改变凝血诊断。在本文中,我们提出了一个定制的动态微流控系统,该系统可以在单个微通道上评估多种剪切速率条件下的凝血反应。该系统采用先进的流体控制系统,可实现高通量测试,对平台内的血流状况进行快速、精确的调节。我们提出的实验结果表明,该平台有潜力发展成为一种高通量、低成本的凝血诊断设备。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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