Estimation of malondialdehyde and catalase activity in pregnant women at IIMS&R Hospital, Lucknow, India

N. Singh, Saba Khan, M. Khan, H. Ahsan, Roshan Alam
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Abstract

Background: During pregnancy, the physiological production of reactive oxygen species (ROS) is associated with a variety of maternal, placental, and fetal developmental functions. These functions are disrupted by excessive amounts of ROS, resulting to pregnancy complications. Different stages of pregnancy require a balance between oxidant and antioxidant production. Objective: The aim of this study is to investigate the status of malondialdehyde (MDA) and catalase (CAT) activity in pregnant and age matched non-pregnant women. Methods: In this cross-sectional study, a total of 74 participants were enrolled, including 37 pregnant and 37 age-matched non-pregnant women. The age range of participants was 18 to 40 years. MDA and CAT levels were measured spectrophotometrically. A p-value 0.05 was statistically significant. Results: Compared to non-pregnant women, the mean plasma level of MDA was considerably elevated in pregnant women (p<0.0001). However, the mean level of CAT activity in pregnant women was significantly lower than in non-pregnant women (p<0.0001) In pregnant women, there is a significant strong negative correlation between MDA levels and CAT activity (p<0.01). Conclusion: Pregnant women have high level of oxidative stress, indicating that the pregnant women are more susceptible to oxidative damage and may develop pregnancy-associated complications.  
印度勒克瑙IIMS&R医院孕妇丙二醛和过氧化氢酶活性的评估
背景:在怀孕期间,活性氧(ROS)的生理产生与母体、胎盘和胎儿的多种发育功能有关。这些功能被过量的活性氧破坏,导致妊娠并发症。怀孕的不同阶段需要平衡氧化剂和抗氧化剂的产生。目的:本研究的目的是探讨丙二醛(MDA)和过氧化氢酶(CAT)活性的孕妇和年龄匹配的非孕妇的状态。方法:本横断面研究共纳入74名参与者,其中37名孕妇和37名年龄匹配的非孕妇。参与者的年龄范围为18至40岁。分光光度法测定丙二醛和CAT水平。p值0.05有统计学意义。结果:与未妊娠妇女相比,妊娠妇女血浆MDA水平显著升高(p<0.0001)。但孕妇血清中CAT活性的平均值明显低于非孕妇(p<0.0001)。在孕妇血清中,MDA水平与CAT活性呈显著的强负相关(p<0.01)。结论:孕妇氧化应激水平较高,表明孕妇更易发生氧化损伤,并可能发生妊娠相关并发症。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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