Intraoperative Midazolam Induced Myoclonus - A Case Report

Abstract

Myoclonus has been defined as sudden, brief, jerks, twitching or spasm of a muscle or a group of muscles that can be generated by any area in the central nervous system. Drugs administered through intrathecal and epidural routes and sedatives like benzodiazepines and opioids intravenously can occasionally cause myoclonus. The differential diagnoses of myoclonus following IV administration of midazolam are many. Inj midazolam may be responsible for acute myoclonus in our patient. The exact mechanism is not known. Extensive studies of the cause of myoclonus with midazolam have remained an enigma.