Modeling and simulation analysis of Salmonella typhimurium inside human epithelial cells: Host-pathogen relationship analysis by system biology

Abstract

Bacteria have the tendency to acquire resistance and develop defense from drug which makes pharmaceutical industries to work and develop new strategies for producing effective antibiotics against them. With molecular advancement and better understanding to their pathway architecture, channel for developing better antibiotics is open. Here we try to understand the enzyme kinetics of each protein and system biology of Salmonella typhi and infected host cell by its virulence factors. With taking in consideration, we have identified expressed protein CDC42, HiLD, and Arp2/3 complex protein in disease state when pathogen attacks the host. This study opens target for developing future drugs against salmonella typhi infection.