Acquired prothrombin complex deficiency: Case reports

Abstract

Introduction: Acquired prothrombin complex deficiency (APCD) is a spontaneous hemorrhage due to decreased activity of vitamin K dependent coagulation factor (factor II, VII, IX, and X). Many factors lead to vitamin K deficiency in newborns. We reported case reports of APCD which were successfully managed with APCD guidelines. Case presentation: First case was baby aged 1 month who came to emergency ward due to seizure four times. Seizures were occurred for 30 minutes and reported unconscious between episode of seizure. Head computed tomography (CT) scan examination revealed crescent shape appearance which suggested subdural hematoma (SDH). Second case was a 2 months old baby came to emergency department unconsciously since two days before. Patient has no history of vomiting and seizures. Non-contrast head CT scan showed appearance of crescent shape, which suggested presence of SDH. Both patients were managed according to APCD guidelines and had improved. Conclusion: Mild APCD has good prognosis and showing improvement in 24 hours after vitamin K injection. The mortality rate is very high in case of severe bleeding in intracranial, intrathoracic, and intraabdominal.