The role of 5´-nucleotidases in function of immune system cells

Abstract

Disorder of purine metabolism, in particular the activity of 5'-nucleotidase, which is one of the key enzymes of the purine cycle, leads to functional inferiority of cells of the immune system. 5'-nucleotidase is considered a marker of the functional maturity of lymphocytes. In our opinion, research of activity of the enzyme at various immunodeficiency conditions can serve not only as additional prognostic criteria but also be essential help both at tactics choice and at an estimation of efficiency of therapy with purine analogs.