CEREBRAL VENOUS THROMBOSIS IN WOMEN OF REPRODUCTIVE AGE: CAUSES AND FEATURES OF THE COURSE

Abstract

Cerebral venous thrombosis (CVT) is a brain lesion due to impaired blood circulation, caused by thrombosis of the intracranial veins and sinuses, leading to an increase in hydrostatic pressure in the proximal veins and capillaries, as a result of which cerebral edema and ischemia develop, and, consequently, cerebral infarction is formed. CVT is especially common in women aged 20 to 35 years, which is largely due to the course of pregnancy and the postpartum period, as well as the use of oral contraceptives. Disturbances in the hemostasis system play a key role in the pathogenesis of these thromboses. Data have appeared on the impact of a novel coronavirus infection on the development of cerebral venous thrombosis, both directly, influencing the mechanisms of thrombosis, and indirectly through the mechanisms of inflammation and endothelial lesion. The article analyzes possible factors in the development of cerebral venous thrombosis, discusses mutually potentiating mechanisms in the presence of several significant prothrombotic diseases in women of reproductive age.