Heterogeneity of presynaptic serotonin receptors on sympathetic neurones in blood vessels.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158838
M Göthert, G J Molderings, K Fink, E Schlicker
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引用次数: 20

Abstract

Presynaptic serotonin (5-HT) receptors on the postganglionic sympathetic nerves, which mediate inhibition of noradrenaline release in blood vessels of various species and which interact with the presynaptic alpha 2-autoreceptors, are heterogeneous. In the rat vena cava, they are of the 5-HT1B subtype, in the pig coronary artery they belong to a novel, so far unknown class of 5-HT receptors, and in the human saphenous vein they could be classified as 5-HT1D. These results point to marked species differences and the need to carry out experiments in human vascular preparations. Presynaptic 5-HT receptors may be involved in the mechanism of action of the new antimigraine drug sumatriptan.

血管交感神经元突触前血清素受体的异质性。
神经节后交感神经上的突触前5-羟色胺(5-HT)受体介导各种血管中去甲肾上腺素释放的抑制,并与突触前α 2-自受体相互作用,是异质性的。在大鼠腔静脉中,它们属于5-HT1B亚型,在猪冠状动脉中,它们属于一种新的,迄今为止未知的5-HT受体类别,在人隐静脉中,它们可归类为5-HT1D。这些结果指出了明显的物种差异和在人体血管制剂中进行实验的必要性。突触前5-羟色胺受体可能参与抗偏头痛新药物舒马匹坦的作用机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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