New T-wave parameters describing repolarization abnormalities induced by drug

Abstract

In this study, we identify additional markers extracted from the T-wave of vectrocadiogram sensitive to the variation induced by drug. These parameters which were not tested before for drug effect evaluation were compared with other T-wave indicators by beat to beat calculation of all parameters using different mathematical tools on the ECG of two patients with nearly 6 hours recordings from a clinical d-Sotalol study. The results confirm the QT-interval prolongation induced by d-Sotalol and show high sensitivity of the new parameters even with reduced concentration of d-Sotalol.