The Combination of L-lysine and Alloxan Induces Acute Necrotizing Pancreatitis in Rats: A Recent Study

Abstract

The purpose of this study was to evaluate the L-lysine effect on the pancreas of induced diabetic rats. Adult male Sprague-Dawley rats were divided into four groups (N = 6 rats per group) and researched for 20 days. Group I: Control (saline solution, i.p.). Group II: Rats treated with 10 mM L-lysine. Group III: Rats treated with 120 mg/kg alloxan (diabetic control). Group IV: Rats treated with alloxan plus L-lysine. Blood was drawn from the aorta to determine glucose, triglycerides, and cholesterol levels. Glucose levels in Group III rats increased as predicted. A loss of body weight was also observed (p < 0.001). On day 10 of the experiment, rats in Group IV had higher glucose concentrations than diabetic control rats. The findings show that L-lysine administration to intact animals had an effect on the pancreas. Pancreatic damage was increased in animals that had previously received alloxan injections. It is obvious that a single dose of L-lysine resulted in hyperglycemia. When L-lysine is combined with alloxan, this effect is amplified. These findings allow us to propose a new model of acute pancreatitis in rats.