Ceftriaxone vs. norfloxacin in the treatment of resistant typhoid fever in 60 children

Abstract

Objective To compare the effect of ceftriaxone and norfloxacin on resistant typhoid fever in children. Methods Sixty children with typhoid fever resistant to chloramphenicol, ampicillin or cotrimoxazole were randomly divided into two groups. Thirty cases received ceftriaxone [100 mg/ (kg·d) , once daily, iv] and the other 30 received norfloxacin [10 mg/ (kg·d) , twice daily] . Result Ceftriaxone was effective in 93% of the 30 cases, while norfloxacin was effective in 80% of the 30 cases (Ridit analysis, ceftriaxon (R = 0.421 1, norfloxacin (R = 0.578 9, u = 2.12, P <0.05) . Conclusion The therapeutic effect of ceftriaxone on drug-resistant typhoid fever in children was better than that of norfloxacin. Key words: Typhoid; Ceftriaxone; Norfloxacin; Child