Some selected haematological indices in Wistar rats in the vanadium-ethanol interaction.

H Zaporowska, W Wasilewski
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Abstract

1. Wistar rats of both sexes daily received an ethanol solution of ammonium metavanadate (AMV) of 0.3 mg V/cm3 5% ethanol concentration as sole drinking liquid, for a period of 4 weeks. 2. The reference groups received for drinking aqueous AMV solution, or 5% ethanol, or water. 3. In animals drinking both water and ethanol AMV solution a decrease in the erythrocyte count and haemoglobin level was noted together with an increase of the percentage of reticulocytes and polychromatophilic erythrocytes in the peripheral blood. 4. A small rise of the percentage of polychromatophilic and orthochromatic erythroblasts was at the same time noted in the bone marrow of animals receiving ethanol AMV solution. 5. In the group of animals drinking 5% ethanol a fall of the erythrocyte count was observed and a rise of the leukocyte count, particularly of lymphocytes. 6. Substitution of water by 5% ethanol solution as solvent for AMV did not have any distinct influence on the toxicity of the tested compound.

钒-乙醇相互作用对Wistar大鼠血液学指标的影响。
1. 雄性和雌性Wistar大鼠每天单独饮用0.3 mg V/cm3 5%乙醇浓度的异氰酸铵(AMV)乙醇溶液,连续4周。2. 参照组分别饮用AMV水溶液、5%乙醇或水。3.在同时饮用水和乙醇AMV溶液的动物中,红细胞计数和血红蛋白水平下降,外周血中网状红细胞和多色红细胞的百分比增加。4. 同时,接受乙醇AMV溶液的动物骨髓中嗜多色红细胞和正色红细胞的百分比略有上升。5. 在饮用5%乙醇的动物组中,观察到红细胞计数下降,白细胞计数上升,特别是淋巴细胞。6. 用5%乙醇溶液代替水作为AMV的溶剂对被试化合物的毒性没有明显的影响。
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