[Effect of naloxone on basal, by somatostatin inhibited stomach secretion in patients with chronic duodenal ulcer].

Abstract

In 13 men with chronic duodenal ulcer disease effects of somatostatin and naloxone on basic gastric secretion were determined. Following intravenous somatostatin infusion a significant increase in basic gastric secretion was observed. Somatostatin also induced a significant increase in sodium concentration and a decrease in chloride concentration in the gastric juice. Total electrolyte and mucoprotein secretions changed proportionally to alterations in the gastric juice volume. Somatostatin-induced gastric secretion was unaffected by a single intravenous naloxone administration. In patients with chronic duodenal ulcer disease somatostatin and naloxone affect gastric secretion independently of each other.