A new method for determining drug half-life and evaluating stability

Abstract

In the measurement system of 4-5 different types of anticancer drugs and commonly used drugs and corresponding solvents, the microcalorimetry was the main research method to determine the dissolving enthalpy of the drug in the corresponding solvent to study the dissolution behaviour of drugs in solvents. According to the established mathematical model of thermodynamics, the dissolution half-life of drugs in the corresponding solvents is calculated, the kinetic equation, kinetic parameters and thermodynamic parameters in the dissolution process are established, and the database of thermodynamic and kinetic parameters of the anticancer drugs and commonly used drugs is established, which provides a theoretical basis for the stability evaluation and clinical application of drugs..