Association between P561T polymorphism in growth hormone receptor gene and mandibular prognathism: systematic review and metaanalysis

Mariele Andrade do Nascimento, D. B. Oliveira, C. Reis, L. Wambier, K. C. Horta, F. Romano, L. Silva, R. A. B. Silva, P. Nelson-Filho, E. Küchler
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引用次数: 3

Abstract

Objective: Through a systematic review and meta-analysis, the aim this study was evaluating the association between the P561T polymorphism in GHR (rs6184) with skeletal Class III malocclusion in different populations. Methods: A broad search for studies was conducted using the databases: PubMed, Web of Science, Scopus, Cochrane, Google Scholar and Open Grey until December 2018. The study design according to PECOS was: P-Orthodontic patients; E- polymorphism P561T in GHR; C- absence of polymorphism P561T in GHR; O- linear dimension alterations in maxilla and mandibular measurements; S- Cross-sectional studies. The selected studies were qualified by 10-point scoring sheet methodological quality. The subgroups evaluation was performed according to the linear measurements evaluated in two or more studies, as follows: body height, N-S, A’-PTM’, Gn-Go, Pog’-Go, and Co-Go.A fixed effect model was used and the mean differences were performed using the inverse-variance meta-analysis. The I2 (95%) was used to measure statistical heterogeneity between studies, where I2 values of 25%, 50%, and 75% signified low, medium, and high heterogeneity, respectively. Results: The initial search identified 146 studies. After excluding duplicateabstracts, 138 were selected. Seven studies were included in the systematic review. Only one study was classified as having low methodological quality. Three studies were included in the meta-analysis. The meta-analysis demonstrated an association between the Co-Go linear measure and CC genotype (p<0.0001), with a mean difference and confidence interval of 3.79 [2.06, 5.52]. CC was associated with greater mandibularheight. Conclusion: The polymorphism P561T in GHR is associated with Co-Go measurement in Asians, with low level of evidence.
生长激素受体基因P561T多态性与下颌前伸症的关系:系统回顾和荟萃分析
目的:通过系统回顾和荟萃分析,探讨不同人群GHR基因P561T多态性(rs6184)与骨骼III类错颌合的关系。方法:使用PubMed、Web of Science、Scopus、Cochrane、b谷歌Scholar和Open Grey等数据库进行广泛的研究检索,直至2018年12月。根据PECOS进行研究设计:P-Orthodontic患者;GHR基因E-多态性P561T的研究C- GHR中不存在P561T多态性;上颌和下颌骨测量的O-线性尺寸变化;S-横断面研究。所选研究通过10分计分表方法学质量进行合格评定。亚组评估是根据在两个或多个研究中评估的线性测量值进行的,如下:身高、N-S、A ' -PTM、Gn-Go、Pog ' -Go和Co-Go。采用固定效应模型,均值差异采用反方差荟萃分析。I2(95%)用于衡量研究间的统计异质性,其中I2值为25%、50%和75%分别表示低、中、高异质性。结果:最初的搜索确定了146项研究。在排除重复摘要后,共筛选出138篇。系统评价纳入了7项研究。只有一项研究被归类为低方法学质量。meta分析包括三项研究。meta分析显示Co-Go线性测量与CC基因型之间存在相关性(p<0.0001),平均差异和置信区间为3.79[2.06,5.52]。CC与较大的下颌高度相关。结论:亚洲GHR基因P561T多态性与Co-Go测定有关,但证据水平较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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