MODELING OF POTENTIAL PROTEIN S1 SARS-COV-2 LIGANDS

Abstract

The S1 protein of SARS-CoV-2 (hereinafter referred to as the S1 protein) is probably the main factor in the pathogenesis of COVID-19. In our opinion, the elimination or decrease in the concentration of this protein will reduce the inflammatory process and, accordingly, damage to organs and tissues by the activated immune system. An analysis of the complexes of the Angiotensin-converting enzyme 2 (ACE2) and the S1 protein (ACE2-S1) will determine the oligopeptides that are ligands for binding the S1 protein, the timely removal of which from the blood of patients with COVID-19 will prevent the development of severe multi-organ complications. Besides, the immobilized oligopeptide that binds the S1 protein will be able to remove from the body viral particles located in the extracellular space [1].