In-Home Video and IMU Kinematics of Self Guided Tasks Correlate with Clinical Bradykinesia Scores

Gabrielle Strandquist, Tanner C. Dixon, Tomasz Frączek, Shravanan Ravi, Alicia Zeng, Raphael Bechtold, Daryl Lawrence, S. Little, J. Gallant, Jeffrey A. Herron
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Abstract

Deep brain stimulation (DBS) delivers electrical stimulation directly to brain tissue to treat neurological movement disorders such as Parkinson's Disease (PD). Adaptive DBS (aDBS) is an advancement on DBS that uses symptom-related biomarkers to adjust therapeutic stimulation parameters in real time to improve clinical outcomes and reduce side-effects. A significant challenge for the field of aDBS is developing automated methods to optimize stimulation parameters using remote assessments of symptom severity. To address this challenge, we designed a prototype at-home data collection platform that can remotely update aDBS algorithms and explore objective assessments of motor symptom severity. Our platform collects neural, inertial, and video data, and supports clinician validation of automated symptom assessments. We deployed the system to the home of an individual with PD and collected pilot data across six days. We evaluated motor symptom severity by recording data with stimulation amplitudes set to varying levels during self-guided clinical tasks and free behavior. We assessed movement features including frequency, speed, and peak angular velocity from video-derived pose estimates and inertial data during three clinical tasks. All features showed a reduction during periods of under-stimulation and were significantly correlated with video-based clinical scores of symptom severity (Spearman rank test, $p < 0.006)$. These results demonstrate that our prototype is capable of remote multimodal data collection and that these data can enhance aDBS research outside the clinic.
家庭录像和自我引导任务的IMU运动学与临床运动迟缓评分相关
深部脑刺激(DBS)直接向脑组织提供电刺激,以治疗神经运动障碍,如帕金森病(PD)。适应性DBS (Adaptive DBS, aDBS)是DBS的一项进展,它利用症状相关的生物标志物实时调整治疗刺激参数,以改善临床结果并减少副作用。aDBS领域面临的一个重大挑战是开发自动化方法,通过远程评估症状严重程度来优化刺激参数。为了应对这一挑战,我们设计了一个原型家庭数据收集平台,可以远程更新aDBS算法并探索运动症状严重程度的客观评估。我们的平台收集神经、惯性和视频数据,并支持临床医生对自动症状评估的验证。我们将该系统部署到一位PD患者的家中,并在6天内收集了试验数据。我们通过记录在自我指导的临床任务和自由行为中设置不同水平的刺激幅度的数据来评估运动症状的严重程度。在三个临床任务中,我们评估了包括频率、速度和峰值角速度在内的运动特征,这些特征来自于视频导出的姿态估计和惯性数据。在低刺激期间,所有特征都有所减少,并与基于视频的症状严重程度临床评分显著相关(Spearman秩检验,p < 0.006)。这些结果表明,我们的原型能够远程多模式数据收集,这些数据可以加强临床以外的aDBS研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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