Development and Characterization of Porous PDMS Microneedles

Renata Maia, P. Sousa, V. Pinto, R. Lima, G. Minas, Raquel O. Rodrigues
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Abstract

This study aimed the development and characterization of polydimethylsiloxane (PDMS) porous microneedles (MNs) cast with silica nanoparticles as porogenic material for biomedical applications. To produce the porous PDMS MNs, different concentrations of silica nanoparticles were cast into PDMS, followed by chemical etching to remove the casted material and produce a porogenic network. This chemical etching was achieved using NaOH and it included initial steps for homogenization of the silica material dispersed in ethanol mixed with PDMS and followed by the evaporation of the solvent. Afterwards, the morphology, wettability, air permeability, swelling, porosity, surface chemistry, and mechanical characteristics of the developed porous PDMS MNs were investigated. The results showed that the porosity and mechanical properties of porous MNs could be tailored by varying the porogenic material concentration. Overall, the results of this study suggest that PDMS porous MNs have great potential as platforms for biomedical applications such as drug delivery, designed with a simple and rapid procedure that can be tuned in the detriment of the application.
多孔PDMS微针的研制与表征
本研究旨在开发和表征以二氧化硅纳米颗粒铸造的聚二甲基硅氧烷(PDMS)多孔微针(MNs),并将其作为生物医学应用的致孔材料。为了制备多孔的PDMS MNs,将不同浓度的二氧化硅纳米颗粒浇铸到PDMS中,然后进行化学蚀刻以去除浇铸材料并产生致孔网络。这种化学蚀刻是使用NaOH实现的,它包括分散在与PDMS混合的乙醇中的二氧化硅材料的均质化的初始步骤,然后是溶剂的蒸发。随后,研究了制备的多孔PDMS MNs的形貌、润湿性、透气性、溶胀性、孔隙率、表面化学和力学特性。结果表明,多孔纳米颗粒的孔隙度和力学性能可以通过改变成孔材料的浓度来调整。总的来说,本研究的结果表明,PDMS多孔MNs作为生物医学应用的平台具有巨大的潜力,例如药物输送,其设计具有简单快速的程序,可以在不利于应用的情况下进行调整。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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