Analysis of cardiac involvement in patients recovered from Covid-19 without troponin elevation, evaluated by cardiovascular magnetic resonance.

A. Carlessi, L. Perello, C. Pantaley, A. Borsini, L. Rossi, F. Giménez, Julián Leonardi, Ariel Ballina, M. Maillo, P. Rienzo, P. Gonzalo, Martin Gonzalez Vara, Luciana Vegetti, Sebastián Wustten, Lucas Costa, D. Vergara, Cristian Froullet
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Abstract

Background The disease caused by coronavirus (COVID-19) affects the cardiovascular system, whether by direct viral aggression or indirectly through systemic inflammation and multiple organ compromise. A widely used method to determine cardiac injury is troponin measurement. The aim of this study is to evaluate the prevalence of cardiac involvement (CINV) in a population recovered from COVID-19, referred to cardiac MRI (CMR), who did not present troponin elevation. Methods There were 156 patients that recovered from COVID-19 and who did not present troponin elevation referred to CMR. CINV was considered to be the presence of: late gadolinium enhancement (LGE), edema, myocarditis, pericarditis, left ventricular systolic dysfunction (LVSD) and/or depressed right ventricular systolic dysfunction (RVSD). Results Prevalence of CINV was 28.8%, being more frequent in men (p = 0.002), in patients who required hospitalization (p = 0.04) and in those who experienced non-mild cases of infection (p = 0.007). RVSD (17.9%) and LVSD (13.4%) were the most frequent findings. The rate of myocarditis was 0.6%. LGE manifested in 7.1% of patients and its presence was related to less left ventricular ejection fraction (LVEF) (p = 0.0001) and right ventricular ejection fraction (RVEF) (p = 0.04). Conclusion In patients who recovered from COVID-19, 28.8% of CINV was found. It was more frequent in men, in patients who required admission and in patients with cases of non-mild infection. The patients that presented LGE had less LVEF and RVSF.
无肌钙蛋白升高的Covid-19康复患者心脏受累分析,心血管磁共振评估。
由冠状病毒(COVID-19)引起的疾病影响心血管系统,无论是通过直接病毒攻击还是通过全身炎症和多器官损害间接影响。肌钙蛋白测定是一种广泛使用的测定心脏损伤的方法。本研究的目的是评估从COVID-19恢复的人群中心脏受累(CINV)的患病率,参考心脏MRI (CMR),未出现肌钙蛋白升高。方法156例COVID-19康复患者,无肌钙蛋白升高(CMR)。CINV被认为存在:晚期钆增强(LGE)、水肿、心肌炎、心包炎、左室收缩功能障碍(LVSD)和/或右室收缩功能障碍(RVSD)。结果CINV的患病率为28.8%,以男性(p = 0.002)、住院患者(p = 0.04)和非轻度感染患者(p = 0.007)居多。RVSD(17.9%)和LVSD(13.4%)是最常见的发现。心肌炎发生率为0.6%。7.1%的患者出现LGE, LGE的存在与左心室射血分数(LVEF) (p = 0.0001)和右心室射血分数(RVEF) (p = 0.04)降低有关。结论在COVID-19康复患者中,CINV检出率为28.8%。在男性、需要住院的患者和非轻度感染的患者中更为常见。LGE患者LVEF和RVSF均较低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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