Integration of SBML models for the description of biological system in a lab-on-chip

A. Rezgui, M. Madec, C. Lallement, J. Haiech
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引用次数: 2

Abstract

Lab-on-chips (LOCs) are small systems, which integrate, in the same device, several functions involving chemical analysis with bio-processing functionalities typically performed in a laboratory. As a consequence, it is a multi-domain system that can be described and designed with VHDL-AMS, a hardware description language that natively supports electronics, thermics and fluidics. On the other hand, the biological part of the LOC is often modeled and simulated with languages suitable to the field of biology. One of the most commonly used ones is SBML (System Biology Markup Language). To promote the integration of biological parts of the LOCs in the VHDL-AMS environment, we have developed software that automatically generates the VHDL-AMS models from SBML descriptions. The potential of this tool is illustrated in the context of the design of the lab-on-chip suitable for the detection of micro-pollutants in drinking water.
集成SBML模型在片上实验室中描述生物系统
芯片实验室(loc)是一种小型系统,在同一设备中集成了几种功能,包括化学分析和生物处理功能,通常在实验室中进行。因此,它是一个可以用VHDL-AMS描述和设计的多域系统,VHDL-AMS是一种支持电子学,热学和流体学的硬件描述语言。另一方面,LOC的生物部分通常使用适合于生物学领域的语言进行建模和模拟。其中最常用的一种是SBML(系统生物学标记语言)。为了促进loc生物部分在VHDL-AMS环境中的集成,我们开发了一种软件,可以根据SBML描述自动生成VHDL-AMS模型。该工具的潜力在适合检测饮用水中微污染物的芯片实验室设计的背景下得到说明。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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