Evaluation of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in critical care patients with synthetic cannabinoid (bonzai) intoxication

IF 0.3 Q4 CRITICAL CARE MEDICINE

Egyptian Journal of Critical Care Medicine Pub Date : 2018-04-01 DOI:10.1016/j.ejccm.2018.03.002

Mustafa Kaplan , Alpaslan Tanoglu , Tolga Duzenli , Muhammet Yildirim , Yusuf Serdar Sakin , Musa Salmanoglu , Yalçin Önem

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引用次数: 1

Abstract

Objective

Synthetic cannabinoid drug abuse has been dramatically increasing among young individuals in many countries. There have been reports of serious side effects with SC abuse in these patients. Previous researches have exhibited that neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are associated with mortality and morbidity in many chronic diseases. The aim of this study was to evaluate PLR and NLR in critical care patients with synthetic cannabinoid (bonzai) intoxication.

Materials and methods

One hundred and seven synthetic cannabinoid intoxication patients requiring intensive care and 40 healthy controls were included in the study. Patients characteristics and the complete blood count (CBC) variables, including white blood cell (WBC), hemoglobin (Hb), platelet count, NLR, PLR as well as AST, ALT, albumin total bilirubin, and other routine biochemical parameters were tested. Data analyses were conducted with SPSS-15 software (SPSS Inc., Chicago, Illinois, USA). Statistical significance was set at a p-value of <0.05.

Results

All participants were male, and the mean age of the patients was 21.74 ± 1.57 and healthy controls was 22.62 ± 2.9 years (p > 0.05). All the routine laboratory tests and inflammatory markers (Erythrocyte sedimentation rate and C-reactive protein) were similar between groups. As complete blood cell count; mean WBC values were 9.43 ± 3.27 × 10³/mm³ vs 7.05 ± 2.12 × 10³/mm³ (p < 0.001), mean platelet counts were 237.33 ± 60 × 10³/mm³ vs 263.90 ± 65.98 × 10³/mm³ (p = 0.022), NLR counts were 3.17 ± 1.95 vs 2.32 ± 1.27 (p = 0.003) and PLR values were 114.43 ± 36.39 vs 133.94 ± 45.27 (p = 0.008), in patients and controls, respectively. Cardiac side effects were observed among 36 patients but nobody was died.

Conclusion

Our results exhibited a significant increase of NLR values and decrease of PLR counts among critical care patients with synthetic cannabinoid (bonzai) intoxication. After at least 24 h of intensive care stay without side effects, the patients might transfer out to inpatient clinic for ongoing follow up period and psychiatric consultation.

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合成大麻素中毒重症患者中性粒细胞与淋巴细胞比值(NLR)和血小板与淋巴细胞比值(PLR)的评价

目的在许多国家，年轻人滥用合成大麻素的情况急剧增加。有报道称，这些患者滥用SC会产生严重的副作用。以往的研究表明，中性粒细胞与淋巴细胞比率(NLR)和血小板与淋巴细胞比率(PLR)与许多慢性疾病的死亡率和发病率有关。本研究的目的是评估合成大麻素(bonzai)中毒重症患者的PLR和NLR。材料与方法选取107例需要重症监护的合成大麻素中毒患者和40例健康对照者作为研究对象。检测患者特征及全血细胞计数(CBC)变量，包括白细胞(WBC)、血红蛋白(Hb)、血小板计数、NLR、PLR以及AST、ALT、白蛋白、总胆红素等常规生化参数。采用SPSS-15软件(SPSS Inc.， Chicago, Illinois, USA)进行数据分析。p值为<0.05，具有统计学意义。结果所有参与者均为男性，患者平均年龄21.74 ± 1.57岁，健康对照组平均年龄22.62 ± 2.9 岁(p > 0.05)。所有常规实验室检查和炎症标志物(红细胞沉降率和c反应蛋白)组间相似。如全血细胞计数;意思是白细胞值9.43 ±3.27  × 103 / mm3 vs 7.05 ±2.12  × 103 / mm3 (p & lt; 0.001),意思是血小板计数237.33 ± 60 × 103 / mm3 vs 263.90 ±65.98  × 103 / mm3 (p = 0.022)NLR计数3.17 ±1.95 vs 2.32  ±1.27 (p = 0.003)和PLR值114.43 ±36.39 vs 133.94  ± 45.27 (p = 0.008),分别在病人和控制。在36例患者中观察到心脏副作用，但无人死亡。结论合成大麻素(bonzai)中毒重症患者NLR值显著升高，PLR计数显著降低。经过至少24 h无副作用的重症监护后，患者可转至住院诊所进行持续随访和精神科会诊。

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来源期刊

Egyptian Journal of Critical Care Medicine

自引率

0.00%

发文量

审稿时长

42 weeks

期刊介绍： The Egyptian Journal of Critical Care Medicine is the official Journal of the Egyptian College of Critical Care Physicians, the most authoritative organization of Egyptian physicians involved in the multi-professional field of critical care medicine. The journal is intended to provide a peer-reviewed source for multidisciplinary coverage of general acute and intensive care medicine and its various subcategories including cardiac, pulmonary, neuro, renal as well as post-operative care. The journal is proud to have an international multi-professional editorial board in the broad field of critical care that will assist in publishing promising research and breakthrough reports that lead to better patients care in life threatening conditions, and bring the reader a quick access to the latest diagnostic and therapeutic approaches in monitoring and management of critically ill patients.