Role of Calcium Permeable Channels in Pain Processing

C. Castro-Junior, L. Ferreira, M. Delgado, J. F. Silva, D. C. Santos
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引用次数: 8

Abstract

Calcium-permeable channels control intracellular calcium dynamics in both neuronal and nonneuronal cells to orchestrate sensory functions including pain. Calcium entering the cell throughout these channels is associated with transduction, transmission, processing, and modulation of pain signals. Clinic, genetic, biochemical, biophysical and pharmacological evidence points toward calcium-permeable channels as the key players in acute and persistent pain conditions. Ligand-gated calcium channels such as TRP channels or some subtypes of voltage-gated calcium channels shows abnormal functioning in persis- tent pain states. Also, NMDA receptors can be unlocked from their physiological Mg 2+ blockade under persisten pain states to culminate with central sensitization. The primary goal of this chapter is to present an overview of the functioning of different classes of calcium-permeable channels and how they become altered to modulate the sensation of pain in acute and chronic states. The most important evidence from classical and recent studies will be discussed trying to depict ways of modulating those channels as a strategy for better pain control.
钙渗透通道在疼痛加工中的作用
钙渗透通道控制神经元和非神经元细胞内钙动力学,以协调包括疼痛在内的感觉功能。钙通过这些通道进入细胞,与疼痛信号的转导、传递、处理和调节有关。临床、遗传、生化、生物物理和药理学证据表明钙渗透通道是急性和持续性疼痛的关键因素。配体门控钙通道如色氨酸通道或电压门控钙通道的某些亚型在持续性疼痛状态下表现出异常功能。此外,NMDA受体可以从持续疼痛状态下的生理Mg 2+封锁中解锁,最终达到中枢致敏。本章的主要目的是概述不同类型的钙渗透通道的功能,以及它们如何改变以调节急性和慢性状态下的疼痛感觉。我们将讨论经典和最新研究中最重要的证据,试图描述调节这些通道的方法,作为一种更好地控制疼痛的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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