S100B PROTEIN CONTENT IN ISCHEMIC STROKE AND ITS PROGNOSTIC VALUE IN PATIENTS SUBJECTED TO INVASIVE INTERVENTIONS

Abstract

The aim of the study is to determine the levels of the S100B protein in patients with ischemic stroke and evaluate its relationship with the size of brain tissue damage, stroke severity, and clinical outcomes. Materials and methods.The study included 113 patients with acute ischemic stroke, hospitalized within the first day after its onset and subjected to invasive treatment. 101 men and 12 women were examined, including 32 at the age of 50-60, 64 at the age of 61-70, 17 at the age of 71-80. parameters and degree of functional deviations according to the NIHSS scale. Results. The content of S100B during the initial determination on average for the group significantly exceeded the level determined in the control by 3.22 times (p=0.025). There was a direct dependence of the content of S100B on the size of the stroke. A moderate increase in the indicator on the 3rd day relative to the determined one on the 1st day and a decrease on the 7th day after the development of the stroke were revealed. There was no significant dependence of S100B content on the presence of comorbidities. The influence of the studied parameter on the degree of neurological deficit was determined only in patients with a large stroke size.