[Methods in individualized pharmacotherapy of diseases of the digestive and the respiratory systems in children].

Abstract

The possibility to forecast pharmacotherapeutic effect in children with chronic diseases of breathing and digestion was studied. It was established that the use of pathogenic and associative markers, characteristic of the background state of a child as compared to individual peculiarities of pharmacokinetics and pharmacodynamics of a certain drug, will allow to forecast the efficiency of drug treatment of chronic diseases of breathing organs (bronchitis, pneumonia, asthmatic bronchitis) and digestion (gastritis, cholecystocholangitis). The use of aminophenazone marker in children with above mentioned pathology became the basis of research into efficiency of spasmolytics with similar type of metabolism (papaverini hydrochloridum, aminophyllinum, drotaverinum). Mathematic models of spasmolytics efficiency forecast was developed by many factor computer analysis.