Çocuklarda idrar yolu enfeksiyonu etkenlerinin dağılımı ve antibiyotik duyarlılığı ve dirençlerinin değerlendirilmesi: Tek merkez deneyimi

Abstract

Aim: Urinary tract infections (UTIs) are one of the most common bacterial infections and potentially serious bacterial infection in childhood. We aimed to determine the common agents and antibiotic sensitivity and resistance status according to the results of urine culture in children diagnosed with urinary tract infection. Materials and Methods: In this retrospective study, we evaluated causative agents and antimicrobial sensitive and resistance in positive urine isolates from the children admitted to our hospital's Pediatrics Clinic between January 2017 and August 2022. Results: A total of 702 positive urine cultures were identified, of which 239 (34%) were from boys and 463 (66%) were from girls. The girl: boy ratio was 1.93. The median age of the patients was 1.1 years (interquartile range, 5.4). The four most frequently detected microorganisms in urine cultures were Escherichia coli (52.3%), Klebsiella pneumoniae (16.1%), Enterococcus faecalis (7.8%) and Proteus mirabilis (6.4%), respectively. Escherichia coli (9.7% vs. 42.6%) and Klebsiella pneumoniae (8.3% vs. 7.8%) were the two most common uropathogens both in boys and girls. Escherichia coli and Klebsiella pneumoniae were highly resistant to ampicillin and 3rd generation cephalosporins, while highly sensitive to aminoglycosides, meropenem and imipenem. Conclusion: We found that E.coli was the most common uropathogen in children with UTIs consistent with the literature. We suggest that when arranging the treatment of children with urinary tract infections in our region, antibiotic resistance should be considered.