Practical functional and washing droplet routing for cross-contamination avoidance in digital microfluidic biochips

Qin Wang, Yiren Shen, Hailong Yao, Tsung-Yi Ho, Yici Cai
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引用次数: 23

Abstract

In digital microfluidic biochips, cross-contamination of different biomolecule droplets is a major issue. Washing operations are introduced to clean the cross-contamination sites. Existing works have oversimplified assumptions on the washing behavior, which either assume unrealistic infinite washing capacity, or ignore the execution time constraint and/or the routing conflicts between functional and washing droplets. This paper presents the first practical droplet routing flow, which considers realistic issues including the finite washing capacity constraint, and the routing conflicts between washing and functional droplets. Effectiveness of the presented method are validated by real-life biochemical applications.
数字微流控生物芯片中避免交叉污染的实用功能和洗涤液滴路径
在数字微流控生物芯片中,不同生物分子液滴的交叉污染是一个主要问题。引入洗涤操作来清洁交叉污染场所。现有工作对洗涤行为的假设过于简单化,要么假设不切实际的无限洗涤容量,要么忽略了执行时间约束和/或功能滴与洗涤滴之间的路由冲突。本文提出了第一个实用的液滴路径流,该流考虑了有限洗涤能力约束以及洗涤液滴与功能液滴之间的路径冲突等现实问题。通过实际生化应用验证了该方法的有效性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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