Enfermedad de Vogt-Koyanagi-Harada

Anne Riveros Frutos , Pau Romera Romero , Susana Holgado Pérez , José Ramón Anglada Escalona , Melania Martínez-Morillo , Beatriz Tejera Segura
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引用次数: 19

Abstract

The Vogt-Koyanagi-Harada (VKH) disease, formerly known as uveomeningitic syndrome, is a bilateral diffuse granulomatous panuveitis associated with exudative retinal detachment, which can be accompanied by central nervous system involvement, dermatological and auditory alterations.

Its name derives from the authors who first described the disease. It affects adults of both genders, between 20 and 50 years old, with darkly pigmented races prevalence. This inflammatory syndrome is probably the result of an autoimmune mechanism, influenced by genetic factors.

The evolution of the disease is divided into four clinical stages: prodromal, acute uveitic, convalescent and chronically recurrent. The diagnosis is mainly clinical, using the criteria established by the American Society of Uveitis (AUS) posted in the year 2001. Differential diagnosis must be done with sympathetic ophthalmopathy, primary B cell lymphoma, posterior scleritis, and uveal effusion syndrome. An early and maintained treatment is the basis of a favorable outcome.

Vogt-Koyanagi-Harada病
Vogt-Koyanagi-Harada (VKH)病,以前称为葡萄膜脑膜炎综合征,是一种双侧弥漫性肉芽肿性全葡萄膜炎,伴有渗出性视网膜脱离,可伴有中枢神经系统受损伤、皮肤和听觉改变。它的名字来源于最早描述这种疾病的作者。它影响20至50岁的男女成年人,以肤色深的种族为主。这种炎症综合征可能是受遗传因素影响的自身免疫机制的结果。该病的发展分为四个临床阶段:前体期、急性葡萄膜期、恢复期和慢性复发期。诊断主要是临床,使用美国葡萄膜炎协会(AUS)在2001年发布的标准。交感性眼病、原发性B细胞淋巴瘤、后巩膜炎和葡萄膜积液综合征必须进行鉴别诊断。早期持续治疗是获得良好结果的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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