Advances in the diagnosis and management of small bowel neuroendocrine tumours

A. Nezhentsev
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Abstract

Small bowel neuroendocrine tumours (SBNETs) are neoplasms arising from the neuroendocrine cells of the small intestine. SBNETs are the most common tumours of the small bowel. Their often unspecific symptoms mean that many patients present late with metastatic disease, most commonly to local lymph nodes, small bowel mesentery, and the liver. Although Somatostatin Analogues (SSAs) can relieve symptoms and slow disease progression, surgical resection remains the only curative option. In this case report, a patient undergoes surgical resection of her primary SBNET and several liver metastases. During the operation it becomes apparent that much of the metastatic liver spread is unresectable, and the aim of the surgery becomes tumour de-bulking. This report reveals the limitations of current SBNET imaging, biomarkers and surgical techniques, and explores recent advances.
小肠神经内分泌肿瘤的诊断和治疗进展
小肠神经内分泌肿瘤(SBNETs)是由小肠神经内分泌细胞引起的肿瘤。SBNETs是小肠最常见的肿瘤。他们通常没有特异性的症状,这意味着许多患者表现为晚期转移性疾病,最常见的转移到局部淋巴结、小肠肠系膜和肝脏。虽然生长抑素类似物(SSAs)可以缓解症状和减缓疾病进展,手术切除仍然是唯一的治疗选择。在这个病例报告中,患者接受手术切除了她的原发性SBNET和几个肝转移灶。在手术过程中,很明显,大部分转移性肝脏扩散是不可切除的,手术的目的是切除肿瘤。本报告揭示了当前SBNET成像、生物标志物和手术技术的局限性,并探讨了最近的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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