Yetişkin Bir Hastada Glioblastoma Multiforme’nin Spinal Kord Tutulumu: Bir Olgu Sunumu

Abstract

Glioblastoma Multiforme (GBM) is a primary malignant neoplasm of the central nervous system which has aggresive progression and mostly seen in adults. Glioblastoma can be scattered aside by using various ways. Intraparenchymal spread by using white matter tracts is the most known way of spreading. Dissemination of glioblastoma through cerebrospinal fluid (CSF) can happens, causing drop metastases, leptomeningeal spread (LMS) and spinal metastasis. Treatment guideline for LMS in patients with GBM has never been prepared. However total sur¬gical removal of the tumor is the accepted treatment of GBM. Patients with weakness of the spinal cord or little number of solitary metastases may have odds from intervention, but more the disease burden rising, palliative radiotherapy (RT) and chemotherapy (CT) might be more effective. Consequently modern literature accepts the treatment for GBM as combined process of -surgical, concurrent chemoradiotherapy, adjuvant chemotherapy- We present a case in which we applied radiotherapy because of spinal cord metastasis that developed after GBM treatment in an adult patient. Through these observations, we analyze the clinical, histological and therapeutic features of this tumor.