New approaches to drug design and delivery based on drug-membrane interactions.

Drug design and delivery Pub Date : 1991-04-01
L G Herbette, D G Rhodes, R P Mason
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Abstract

In this review, the complex physical and chemical interactions of drugs with model and biological membranes under normal and pathological conditions are examined at the molecular level. The results of our own published and unpublished structural studies are discussed and correlated with kinetic binding studies to assess the potential role of nonspecific drug interaction with the membrane bilayer in the overall receptor binding mechanism for membrane-bound receptors in heart and brain.

基于药物-膜相互作用的药物设计和递送新方法。
本文从分子水平研究了正常和病理条件下药物与模型膜和生物膜之间复杂的物理和化学相互作用。我们对已发表和未发表的结构研究结果进行了讨论,并将其与动力学结合研究相关联,以评估非特异性药物与膜双分子层相互作用在心脏和大脑膜结合受体的整体受体结合机制中的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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