Effect of Nigella sativa Linn (Ranunculaceae) ground seed extract on carrageenan induced inflammation in rats

Ibrahim Medical College Journal Pub Date : 2012-02-19 DOI:10.3329/IMCJ.V5I1.9857

S. Parveen, S. C. Bachar, Z. A. Begum

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引用次数: 3

Abstract

Nigella sativa Linn (Family: Ranunculaceae) Bengali name “kalo jera” is used as spice in Bengali foods. Native to Western Asia, Turkey, Iraq and Egypt, the black seed oil has been valued for its health benefits for centuries. This plant has been used in traditional medicine for the treatment of stomach aches, asthma, bronchitis, coughs, fevers, tumour and as a tonic. The dried and grounded seed was extracted with ethanol and the extract was evaluated for anti-inflammatory activity in carrageenan induced rat paw edema model. The extracts were administered orally at the doses of 250 and 500 mg/kg body weight, and statistically significant ( p <0.05) anti-inflammatory effects were observed in a dose dependant manner. The extract showed 28.75% and 43.79% inhibition of inflammation at the doses of 250 and 500 mg/kg body weight after first hour of the carrageenan administration which was comparable to that of standard drugs aspirin 40.52% and hydrocortisone 47.71% respectively. The result of this study supported the traditional medicinal uses of this seed. Ibrahim Med. Coll. J. 2011; 5(1): 22-24 Key word: Nigella sativa; inflammation; carrageenan DOI: http://dx.doi.org/10.3329/imcj.v5i1.9857

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黑马籽提取物对卡拉胶诱导大鼠炎症的影响

黑黑的(科:毛茛科)孟加拉语名称“kalo jera”在孟加拉食品中用作香料。黑籽油原产于西亚、土耳其、伊拉克和埃及，几个世纪以来一直因其有益健康而受到重视。这种植物在传统医学中用于治疗胃痛、哮喘、支气管炎、咳嗽、发烧、肿瘤和补品。用乙醇提取干燥和磨碎的种子，并在卡拉胶诱导的大鼠足跖水肿模型中评价提取物的抗炎活性。给药剂量分别为250和500 mg/kg体重，抗炎作用呈剂量依赖性(p <0.05)。角叉菜胶给药1 h后，250 mg/kg和500 mg/kg剂量的提取物对炎症的抑制率分别为28.75%和43.79%，与标准药物阿司匹林(40.52%)和氢化可的松(47.71%)相当。这项研究的结果支持了这种种子的传统药用价值。易卜拉欣·迈德，上校。j . 2011;5(1): 22-24炎症;卡拉胶DOI: http://dx.doi.org/10.3329/imcj.v5i1.9857

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Ibrahim Medical College Journal

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