The GeneCards/spl trade/ family of databases: GeneCards, GeneLoc, GeneNote and GeneAnnot

Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003 Pub Date : 2003-09-08 DOI:10.1109/CSB.2003.1227357

M. Safran, V. Chalifa-Caspi, O. Shmueli, Naomi Rosen, H. Benjamin-Rodrig, R. Ophir, I. Yanai, M. Shmoish, D. Lancet

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引用次数: 2

Abstract

The popular GeneCards/spl trade/ integrated database of human genes, genomic maps, proteins and diseases has recently spawned three related functional genomics efforts. As sequence data rapidly accumulates, the bottleneck in biology shifts from data production to analysis; researchers seek a profound understanding of the role of each gene, and of the way genes function together. GeneLoc integrates human gene collections by comparing genomic coordinates at the exon level, eliminating redundancies, and assigning unique and meaningful location-based identifiers. GeneCards expression tissue vectors are provided by GeneNote, the first effort to present sophisticated expression analyses for a variety of normal human tissues using the full complement of gene representations (Affymetrix arrays HG-U95A-E). The GeneAnnot system aligns probe-sets with the major public repositories of human mRNA sequences, and provides detailed annotation for each probe-set, with links to GeneCards.

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GeneCards/spl交易/数据库家族:GeneCards, GeneLoc, GeneNote和GeneAnnot

流行的GeneCards/spl贸易/人类基因、基因组图谱、蛋白质和疾病的综合数据库最近产生了三个相关的功能基因组学成果。随着序列数据的迅速积累，生物学的瓶颈从数据产生转向分析;研究人员试图深入了解每个基因的作用，以及基因共同发挥作用的方式。GeneLoc通过比较外显子水平的基因组坐标，消除冗余，并分配独特且有意义的基于位置的标识符，集成了人类基因集合。GeneCards表达组织载体由GeneNote提供，这是首次使用完整的基因表示(Affymetrix阵列ug - u95a - e)对各种正常人体组织进行复杂的表达分析。GeneAnnot系统将探针集与人类mRNA序列的主要公共存储库进行比对，并为每个探针集提供详细的注释，并链接到GeneCards。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003

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