An optical sensor for propagation analysis of Lymphocyte cell for cancer cell detection

2014 IEEE Global Humanitarian Technology Conference - South Asia Satellite (GHTC-SAS) Pub Date : 2014-09-01 DOI:10.1109/GHTC-SAS.2014.6967565

Poonam Sharma, Preeta Sharan

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引用次数: 5

Abstract

Photonic crystal biosensors are highly sensitive devices for detection and analysis of bio-analytes that combines biological components with a physicochemical detector using phonon vibrations. Early stage cancer cell detection is currently the need of the hour. In this paper we have demonstrated a 2-dimensional grating based photonic crystal based biosensor for complete analysis of normal healthy Lymphocyte cell and its components for early stage detection of cancer. Finite Difference Time Domain (FDTD) method has been used for the analysis of the cell. MEEP and MATAB simulation tools have been used for modeling and designing of photonic crystal based sensor and the intensity levels of transmission and reflection spectrums have been observed. It has been observed from the band structure that for little change in refractive index (RI) there will be a significant shift in the frequency and hence it acts as a sensor. This indicates that it is highly sensitive for the change in refractive index and thus it can differentiate between different components of the Lymphocyte cell as well as normal and cancerous cell.

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一种用于淋巴细胞繁殖分析的光学传感器，用于癌细胞检测

光子晶体生物传感器是用于检测和分析生物分析物的高灵敏度设备，它将生物成分与使用声子振动的物理化学检测器相结合。早期癌细胞检测是当前的当务之急。在本文中，我们展示了一种基于二维光栅的光子晶体生物传感器，用于对正常健康淋巴细胞及其成分的完整分析，用于癌症的早期检测。采用时域有限差分法(FDTD)对细胞进行了分析。利用MEEP和MATAB仿真工具对基于光子晶体的传感器进行了建模和设计，并对其透射光谱和反射光谱的强度水平进行了观测。从带结构上观察到，对于折射率(RI)的微小变化，频率会发生显著的变化，因此它可以作为传感器。这表明它对折射率的变化非常敏感，因此它可以区分淋巴细胞的不同成分以及正常细胞和癌细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2014 IEEE Global Humanitarian Technology Conference - South Asia Satellite (GHTC-SAS)

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