The fuzzification of platelet aggregation response for interpretation of interactive effect of combination aspirin-ticlopidine therapy in patients with stroke

Abstract

Current therapy for the prevention of heart attack and stroke includes the use of aspirin and other antiplatelet agents. The latter are used in an all-or-none fashion, one dosage for all. Recent studies suggest that different people respond to different dosages of an antiplatelet agent to a certain degree, and that this response has clinical importance in relation to their intended preventive purpose. This study uses fuzzy theory to describe and study individual responses to the antiplatelet medications aspirin and ticlopidine, alone and in combination.